Investigation of CYP1B1*3 and CYP1B1*4 polymorphisms in a Turkish population

CYP1B1 is a P450 enzyme involved in activating pro-carcinogens to carcinogens as well estrogen metabolism. In order examine the effect of on cancer metabolism, it should be compared with healthy individuals and whether polymorphism between sick significant. This study aims screen CYP1B1*3 CYP1B1*4 polymorphisms group who have not been diagnosed genetic differences metabolic enzymes Turkish population.This cross-sectional type descriptive study.The included 295 patients without diagnosis. The research sample includes applied Ankara University Medical Faculty Hospital Afyonkarahisar Health Sciences Research Application Hospital. signed voluntary consent forms before participation, 3 ml blood samples were taken from each. DNA obtained using isolation kit, then was determined by real-time PCR. distribution determined. frequency CYP1B1*1/*1 (wild type), CYP1B1*1/*3 (heterozygous) and, CYP1B1*3/*3 (mutant) genotypes found 39.33%, 50.67% 10.0% respectively. CYP1B1*1/*4 CYP1B1*4/*4 39.31%, 60.69% 0% No mutant genotype detected this (CYP1B1*4).The results show that frequencies gene population are similar other Caucasian populations. However, did similarity races terms polymorphism.